Articles

Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells

【Author】

He Xu;Chunmei Yue;Ting Zhang;Yuanyuan Li;Ao Guo;Jiaoyang Liao;Gang Pei;Jinsong Li;Naihe Jing;

【Institution】

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;School of Life Science and Technology, Shanghai Tech University;

【Abstract】

<正>Dear Editor,Haploid embryonic stem cells(ha ESCs)hold great potential for genetic screening and the analysis of recessive phenotypes.Several studies have recently reported the generation of mammalian ha ESCs through gamete manipulation,and evaluated the benefits of using them for studying functional genomics in different mammals[1–4].These ha ESCs have been shown to give rise to three germ

【Keywords】

recessive;haploid;genomics;screening;embryonic;manipulation;pluripotent;maintenance;panel;Mouse;

【Source】

Neuroscience Bulletin