A prospective analysis of factors that influence weight loss in patients undergoing radiotherapy

【Author】

Jon Cacicedo;Francisco Casquero;Lorea Martinez-Indart;Olga del Hoyo;Alfonso Gomez de Iturriaga;Arturo Navarro;Pedro Bilbao;Department of Radiation Oncology,Cruces University Hospital;Department of Statistics and Epidemiology,Cruces University Hospital;Department of Radiation Oncology,Catalan Institute of Oncology,L′Hospitalet de Llobregat;

【Institution】

Department of Radiation Oncology,Cruces University Hospital;Department of Statistics and Epidemiology,Cruces University Hospital;Department of Radiation Oncology,Catalan Institute of Oncology,L′Hospitalet de Llobregat;

【Abstract】

Malnutrition occurs frequently in patients with cancer.Indeed,a variety of nutritional and tumorrelated factors must be taken into account in these patients.Recognizing this relationship,we aimed to prospectively evaluate the risk factors that influence weight loss in patients undergoing radiotherapy with oral nutritional supplementation and dietetic counseling.Weight loss of 74 patients during radiotherapy and 1 month after treatment was analyzed.Parameters such as age,gender,tumor location,tumor stage,Eastern Cooperative Oncology Group performance status(ECOG PS)score,and the use of chemotherapy were analyzed to evaluate their influence on weight loss.All patients underwent oral nutritional supplementation and dietetic counseling.Forty-six(65.7%)patients lost weight,with a mean weight loss of(4.73±3.91)kg,during radiotherapy.At 1 month after treatment,45(66.2%)patients lost weight,presenting a mean weight loss of(4.96±4.04)kg,corresponding to a(6.84±5.24)%net reduction from their baseline weight.Head and neck cancer patients had a mean weight loss of(3.25±5.30)kg,whereas the remaining patients had a mean weight loss of(0.64±2.39)kg(P=0.028)during radiotherapy.In the multivariate analysis,the head and neck tumor location(P=0.005),use of chemotherapy(P=0.011),and ECOG PS score of 2-3(P=0.026)were considered independent risk factors.Nutritional status and parameters,such as tumor location(especially the head and neck),the use of chemotherapy,and the ECOG PS score,should be evaluated before radiotherapy because these factors can influence weight loss during radiotherapy and 1 month after treatment.

【Keywords】

Nutrition,radiotherapy,weight loss,oral nutrition supplementation

References

To explore the background and basis of the node document

Springer Journals Database

Total: 28 articles

  • [1] Ling Guo1,2,Huan-Xin Lin1,3,Min Xu1,2,Qiu-Yan Chen1,2,Cheng-Tao Wang1,2,Pei-Yu Huang1,21.State Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.China 2.Department of Nasopharyngeal Cancer,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.China 3.Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.China, Phase I study of TPF neoadjuvant chemotherapy followed by radical radiotherapy in advanced nasopharyngeal carcinoma, Chinese Journal of Cancer,
  • [2] Rebecca J. Stratton;;Marinos Elia, A review of reviews: A new look at the evidence for oral nutritional supplements in clinical practice, Clinical Nutrition Supplements,
  • [3] Faith D. Ottery, Definition of standardized nutritional assessment and interventional pathways in oncology, Nutrition,
  • [4] Allen M. Chen;;Bao-Qing Li;;Derick H. Lau;;D. Gregory Farwell;;Quang Luu;;Kerri Stuart;;Kathleen Newman;;James A. Purdy;;Srinivasan Vijayakumar, Evaluating the Role of Prophylactic Gastrostomy Tube Placement Prior to Definitive Chemoradiotherapy for Head and Neck Cancer, International Journal of Radiation Oncology, Biology, Physics,

More>>

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 43 articles

More>>