来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的Ⅱ期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)

【Author】

Ji-Yeon Kim;Seri Park;Seock-Ah Im;Sung-Bae Kim;Joohyuk Sohn;Keun Seok Lee;Yee Soo Chae;Ki Hyeong Lee;Jee Hyun Kim;Young-Hyuck Im;Tae-Yong Kim;Kyung-Hun Lee;Jin-Hee Ahn;Gun Min Kim;In Hae Park;Soo Jung Lee;Hye Sook Han;Se Hyun Kim;Kyung Hae Jung;Yeon Hee Park;

【Institution】

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine;Department of Health Sciences and Technolog y, Samsung Advanced Institute for Health Sciences and Technolog y, Sungkyunkwan University;Department of Internal Medicine, Seoul National University Hospital, Cancer Research Institute, College of Medicine, Seoul National University;Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine;Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine;Center for Breast Cancer, National Cancer Center;Department of Internal Medicine, Kyungpook National University Hospital;Deparment of Internal Medicine, Chungbuk National University Hospital;Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine;Korean Cancer Study Group;

【Abstract】

背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似。在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表–紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL)。方法使用韩国版的FACT-Taxane问卷评估QoL。在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL。使用线性混合模型评估EG组和PG组QoL的差异。结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复。EG组和PG组之间的基线QoL评分没有差异。在治疗期间,除了第11个疗程外,在第2–13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P <0.05)。神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P <0.001)。结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生。因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品。

【Keywords】

转移性乳腺癌;;艾日布林;;紫杉醇;;神经病;;生活质量;;癌症患者生命质量测评量表–紫杉烷问卷

References

To explore the background and basis of the node document

Springer Journals Database

Total: 9 articles

  • [1] Sherry Wolf;;Debra Barton;;Lisa Kottschade;;Axel Grothey;;Charles Loprinzi, Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies, European Journal of Cancer,
  • [2] Joseph A. Sparano;;Molin Wang;;Silvana Martino;;Vicky Jones;;Edith A. Perez;;Tom Saphner;;Antonio C. Wolff;;George W. Sledge;;William C. Wood;;Nancy E. Davidson, Weekly Paclitaxel in the Adjuvant Treatment of Breast Cancer, The New England Journal of Medicine,
  • [3] DavidCella;AmyPeterman;StacieHudgens;KimberlyWebster;Mark A.Socinski, Measuring the side effects of taxane therapy in oncology, Cancer,
  • [4] Javier Cortes;;Joyce O'Shaughnessy;;David Loesch;;Joanne L Blum;;Linda T Vahdat;;Katarina Petrakova;;Philippe Chollet;;Alexey Manikas;;Veronique Diéras;;Thierry Delozier;;Vladimir Vladimirov;;Fatima Cardoso;;Han Koh;;Philippe Bougnoux;;Corina E Dutcus;;Seth Seegobin;;Denis Mir;;Nicole Meneses;;Jantien Wanders;;Chris Twelves, Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study, The Lancet,

More>>

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 0 articles