The Natriuretic Peptides as Biomarkers for Patients with Congenital Heart Disease


Amiram Nir;


<正>The remarkable improvement in survival of patients with congenital disease has led to a continuously growing number of children and adults with congenital heart disease.It is estimated that the incidence of congenital heart disease is 8 per 1000 live births and there are 3 adults with congenital heart disease per 1000 population.Congenital heart diseases can be divided into lesions that cause volume load due to left to right shunt or valve regurgitation,lesions that cause pressure load due to obstruction, and cyanotic lesions.Some patients have combination of the above.Many patients undergo repair via surgery or catheterization. B-type natriuretic peptide(BNP) is secreted from cardiac myocytes in response to muscle stretch and other stimuli.BNP and N-terminal-pro-B-type natriuretic peptide(NT-proBNP) have emerged as important markers for heart disease in adults with acquired heart disease.It is becoming evident that these peptides may also be important markers in infants,children and adults with congenital heart disease.The present knowledge on the levels and potential use of these peptides in different ages and lesions will be presented.The contribution of these markers for the detection of the presence and severity of disease as well as prognosis will be discussed.


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