<正>Many drugs are of very poor water solubility,so they tend to be eliminated from the gastrointestinal tract before they could be absorbed into the blood circulation.This results in low bioavailability and poor dose proportionality,and therefore leads to an overall inefficient treatment for the patients. Physical modifications used to enhance the dissolution rate as well as bioavailability of poorly water soluble drugs mainly focus on increasing the surface area,solubility and wettability of the drug particles by particle size reduction and generation of amorphous states.The particle size of several poorly water soluble drugs(artemisinin,quercetin,curcumin,glibenclamide,hesperetin,silymarin) was successfully reduced by employing three fabrication methods namely,spray drying,antisolveni precipitation with a syringe pump(APSP),and evaporative precipitation of nanosuspension(EPN). The spray drier produced microparticles of drugs and the particle size was further reduced by using the APSP method.Finally,the nanoparticles of the drugs were successfully prepared by the newly developed EPN method.The dissolution rate of the drug nanoparticles prepared by the EPN method exhibited many folds increase in the dissolution rate of the drugs.The APSP and EPN method developed in this study have been found to be effective in decreasing the particle size of drugs and hence,increasing their dissolution rate.These methods also have advantages such as being less energy intensive and less time consuming,using low-cost set up and low temperature and pressure conditions,which protect sensitive drugs.Moreover,no impurities are introduced and no toxic surfactants or stabilizers are used.The enhanced dissolution of the drug nanoparticles and dispersions can potentially translate into an increased bioavailability in-vivo.This will lead to considerable dose reduction for patients.
Fabrication of Micro/Nano-particles of Drugs for Pharmaceutical Applications;
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