Renal Sympathetic Denervation Suppresses Atrial Fibrillation Induced by Acute Ischemia/Infarction by Inhibiting Cardiac Sympathetic Activity

【Author】

Qina Zhou;Baopeng Tang;

【Abstract】

(a) Introduction:Whether renal sympathetic denervation(RSD) can reduce atrial fibrillation(AF)inducibility and sympathetic activity/induced by acute ischemia/infarction is not known.In this study,we aimed to explore the effects of renal sympathetic denervation(RSD) on atrial fibrillation(AF)inducibility and sympathetic activity/induced by acute ischemia/infarction.(b) Methods:Acute ischemia/infarction was created in 12 beagle dogs by permanent occlusion of the left circumflx artery(LCX) to induce left atrial ischemia/infarction and left ventricular infarction,occlusion of the right atrial anterior branch and intermediate branch of atrium to induce right atrial ischemia/infarction in addition to sinus node and right ventricular infarction.Six dogs in shamRSD group did not undergo renal sympathetic denervation.Six dogs without coronary artery ligation served as controls.AF induction rate,sympathetic discharge,catecholamine concentration and densities of tyrosine hydroxylase-positive nerves were measured,(c) Results:The AF induction rate in the RSD group and Sham-RSD group was 95.8%and 90.0%,respectively.Acute ischemia/infarction resulted in significant increase of AF induction rate,which was decreased by renal sympathetic denervation compared to Sham(P<0.05).The number of sympathetic discharge were significantly augmented by ischemia relative to baseline and control(P<0.05).The number of sympathetic discharge was significantly reduced by renal sympathetic denervation when compared to control and Sham(P<0.05).Norepinephrine and epinephrine concentration in atria,ventricle and kidney were elevated by ischemia/infarction,while reduced by renal sympathetic denervation(P<0.05).(d) Conclusions:Sympathetic hyperactivity and hyperinnervation are associated with pacing-induced AF after acute ischemia/infarction.Renal sympathetic denervation have the potential to reduce the incidence of new-onset AF after acute ischemia/infarction.The inhibition of cardiac sympathetic activity,rather than by renal sympathetic denervation may be one of the major underlying mechanisms on the marked reduction of AF inducibility.

【Keywords】

Renal Sympathetic Denervation Suppresses Atrial Fibrillation Induced by Acute Ischemia/Infarction by Inhibiting Cardiac Sympathetic Activity;

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