Pharmacological Intervention to Study the Effect of Antinociceptive Curcumin Analogues in a Rat Model of Migraine

【Author】

Yogeswari Perumal;

【Abstract】

Migraine is one of the most common neurological disorders,leading to more than 1%of total disability reported.Three times as many women as men have migraine,and while the mechanism behind this is not well understood.The objective of study is screening of three Curcumin based compounds on experimental model of CFA(complete Freund's adjuant) induced migraine model in rats.Wistar male rats(190-210 g) were housed in standard condition of temperature(25± 30℃)and light.Migraine was induced to all rats except normal control group.For experimental procedure animal were deeply anaesthetized with ketamine.And the thirty minutes before administration of CFA,the respective compound treatment(30 mg/kg) were given to all rats.CFA administration caused a significant increase in level of CGRP,TNF-α,IL-1β after lhr compared with baseline.The intraperitoneal treatment with curcumin,MG2 and MG24 after lhr of administration of CFA led to reduction in CGRP,TNF-α,IL-1β levels.The inhibition of CGRP,TNF-α,IL-1β level by these curcumin compounds offer possible mechanism in part that account for the preventative antimigraine activity.The present study demonstrated that the application of CFA onto the dural surface of rat induced changes in the expression of CGRP,TNF-α,IL-1β in the trigeminal ganglion for trigeminovascular activation thereby mimicking physiological migraine states.The screening of Curcumin and its analogues MG2,and MG24 compound on migraine model showed significant antimigraine activity in rats.

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