The Application of Spectral Karyotyping in Leukemia


Bo Guo Wanming Da Xiaoping Han Department of Hematology, General Hospital of the PLA, Beijing 100853, China.


Spectral karyotyping (SKY) is a novel cytogenetic technique, which has been developed to unambiguously display and identify all 24 human chromosomes at one time without previous knowledge of any abnormalities involved. SKY can discern aberrations that fail to be easily detected by conventional banding techniques and by fluorescent in situ hybridization (FISH). Therefore SKY is highly accurate, highly sensitive, and highly prognostic. In this report the featurese and application of SKY in studies of leukemia are reviewed.


spectral karyotyping, chromosomes, cytogenetics, leukemia


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  • [1] E. Schr?ck;;T. Veldman;;Hesed Padilla-Nash;;Y. Ning;;Jack Spurbeck;;Syed Jalal;;Lisa G. Shaffer;;Peter Papenhausen;;Chahira Kozma;;Mary C. Phelan;;Eigil Kjeldsen;;Stephen A. Schonberg;;Patricia O’Brien;;Les Biesecker;;Stan du Manoir;;Thomas Ried, Spectral karyotyping refines cytogenetic diagnostics of constitutional chromosomal abnormalities, Human Genetics,

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