Colorectal cancer carcinogenesis:a review of mechanisms


Kanwal Tariq;Kulsoom Ghias;Department of Biological and Biomedical Sciences, Aga Khan University;


Department of Biological and Biomedical Sciences, Aga Khan University;


Colorectal cancer(CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, Cp G island methylator phenotype, and microsatellite instability. Genetic instability is usually caused by aneuploidy and loss of heterozygosity. Mutations in the tumor suppressor or cell cycle genes may also lead to cellular transformation. Similarly, epigenetic and/or genetic alterations resulting in impaired cellular pathways, such as DNA repair mechanism, may lead to microsatellite instability and mutator phenotype. Non-coding RNAs, more importantly micro RNAs and long non-coding RNAs have also been implicated at various CRC stages. Understanding the specific mechanisms of tumorigenesis and the underlying genetic and epigenetic traits is critical in comprehending the disease phenotype. This paper reviews these mechanisms along with the roles of various non-coding RNAs in CRCs.


Colorectal cancer;;chromosomal instability;;microsatellite instability;;non-coding RNA mismatch repair


To explore the background and basis of the node document

  • [1] Cong Tan, Xiang Du, Department of Oncology, Shanghai Medical School, Fudan University, Shanghai 200032, China , Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai 200032, China, KRAS mutation testing in metastatic colorectal cancer, World Journal of Gastroenterology,
  • [2] Jennifer Raisch,Arlette Darfeuille-Michaud,Hang Thi Thu Nguyen,M2iSH,UMR 1071 Inserm,University of Auvergne,63000 Clermont-Ferrand,France Jennifer Raisch,Arlette Darfeuille-Michaud,Hang Thi Thu Nguyen,INRA USC 2018,63000 Clermont-Ferrand,France Arlette Darfeuille-Michaud,Centre Hospitalier Universitaire,63000 Clermont-Ferrand,France, Role of microRNAs in the immune system,inflammation and cancer, World Journal of Gastroenterology,
  • [3] Fabio Coppedè;Angela Lopomo;Roberto Spisni;Lucia Migliore;Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa;Istituto Toscano Tumori (ITT);Department of Surgery, Medical, Molecular, and Critical Area Pathology, University of Pisa;, Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer, World Journal of Gastroenterology,
  • [4] Verena Stiegelbauer;Samantha Perakis;Alexander Deutsch;Hui Ling;Armin Gerger;Martin Pichler;Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria;Division of Hematology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria;Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States;, MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer, World Journal of Gastroenterology,


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