Genetic and molecular changes in ovarian cancer


Robert L Hollis;Charlie Gourley;Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh;


Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh;


Epithelial ovarian cancer represents the most lethal gynecological malignancy in the developed world, and can be divided into five main histological subtypes: high grade serous, endometrioid, clear cell, mucinous and low grade serous. These subtypes represent distinct disease entities, both clinically and at the molecular level. Molecular analysis has revealed significant genetic heterogeneity in ovarian cancer, particularly within the high grade serous subtype. As such, this subtype has been the focus of much research effort to date, revealing molecular subgroups at both the genomic and transcriptomic level that have clinical implications.However, stratification of ovarian cancer patients based on the underlying biology of their disease remains in its infancy. Here, we summarize the molecular changes that characterize the five main ovarian cancer subtypes, highlight potential opportunities for targeted therapeutic intervention and outline priorities for future research.


ovarian cancer;;molecular genetics;;histological subtypes;;molecular subgrouping;;ovary


To explore the background and basis of the node document

  • [1] Kathleen R. Cho;;Ie-Ming Shih, Ovarian Cancer, Annual Review of Pathology: Mechanisms of Disease,
  • [2] Henry T. Lynch;;Murray Joseph Casey;;Carrie L. Snyder;;Chhanda Bewtra;;Jane F. Lynch;;Matthew Butts;;Andrew K. Godwin, Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management, Molecular Oncology,
  • [3] Samuel C. Mok;;Tomas Bonome;;Vinod Vathipadiekal;;Aaron Bell;;Michael E. Johnson;;kwong-kwok Wong;;Dong-Choon Park;;Ke Hao;;Daniel K.P. Yip;;Howard Donninger;;Laurent Ozbun;;Goli Samimi;;John Brady;;Mike Randonovich;;Cindy A. Pise-Masison;;J. Carl Barrett;;Wing H. Wong;;William R. Welch;;Ross S. Berkowitz;;Michael J. Birrer, A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2, Cancer Cell,
  • [4] Luke Hughes-Davies;;David Huntsman;;Margarida Ruas;;Francois Fuks;;Jacqueline Bye;;Suet-Feung Chin;;Jonathon Milner;;Lindsay A Brown;;Forrest Hsu;;Blake Gilks;;Torsten Nielsen;;Michael Schulzer;;Stephen Chia;;Joseph Ragaz;;Anthony Cahn;;Lori Linger;;Hilal Ozdag;;Elena Cattaneo;;E.S Jordanova;;Edward Schuuring;;David S Yu;;Ashok Venkitaraman;;Bruce Ponder;;Aidan Doherty;;Samuel Aparicio;;David Bentley;;Charles Theillet;;Chris P Ponting;;Carlos Caldas;;Tony Kouzarides, EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer, Cell,


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