Epidemiology of ovarian cancer:a review


Brett M.Reid;Jennifer B.Permuth;Thomas A.Sellers;Department of Cancer Epidemiology,Division of Population Sciences,Moffitt Cancer Center;


Department of Cancer Epidemiology,Division of Population Sciences,Moffitt Cancer Center;


Ovarian cancer(OC) is the seventh most commonly diagnosed cancer among women in the world and the tenth most common in China. Epithelial OC is the most predominant pathologic subtype, with five major histotypes that differ in origination,pathogenesis, molecular alterations, risk factors, and prognosis. Genetic susceptibility is manifested by rare inherited mutations with high to moderate penetrance. Genome-wide association studies have additionally identified 29 common susceptibility alleles for OC, including 14 subtype-specific alleles. Several reproductive and hormonal factors may lower risk, including parity, oral contraceptive use, and lactation, while others such as older age at menopause and hormone replacement therapy confer increased risks. These associations differ by histotype, especially for mucinous OC, likely reflecting differences in etiology. Endometrioid and clear cell OC share a similar, unique pattern of associations with increased risks among women with endometriosis and decreased risks associated with tubal ligation. OC risks associated with other gynecological conditions and procedures, such as hysterectomy,pelvic inflammatory disease, and polycystic ovarian syndrome, are less clear. Other possible risk factors include environmental and lifestyle factors such as asbestos and talc powder exposures, and cigarette smoking. The epidemiology provides clues on etiology,primary prevention, early detection, and possibly even therapeutic strategies.


Ovarian cancer;;epidemiology;;risk factors;;histology;;reproductive history


To explore the background and basis of the node document

  • [1] Kuangrong Wei;Yuanming Li;Rongshou Zheng;Siwei Zhang;Zhiheng Liang;Huishan Cen;Wanqing Chen;Cancer Institute, Zhongshan People’s Hospital;Gynecological and Obstetric Department, Zhongshan People’s Hospital;National Office for Cancer Prevention and Control, National Cancer Center;, Ovary cancer incidence and mortality in China, 2011, Chinese Journal of Cancer Research,
  • [2] Henry T. Lynch;;Murray Joseph Casey;;Carrie L. Snyder;;Chhanda Bewtra;;Jane F. Lynch;;Matthew Butts;;Andrew K. Godwin, Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management, Molecular Oncology,
  • [3] R. Sankaranarayanan;;J Ferlay, Worldwide burden of gynaecological cancer: The size of the problem, Best Practice & Research Clinical Obstetrics & Gynaecology,
  • [4] Robert Baan;;Kurt Straif;;Yann Grosse;;Béatrice Secretan;;Fatiha El Ghissassi;;Vincent Cogliano, Carcinogenicity of carbon black, titanium dioxide, and talc, Lancet Oncology,


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