Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog

【Author】

Armel Herve Nwabo Kamdje;Paul Takam Kamga;Richard Tagne Simo;Lorella Vecchio;Paul Faustin Seke Etet;Jean Marc Muller;Giulio Bassi;Erique Lukong;Raghuveera Kumar Goel;Jeremie Mbo Amvene;Mauro Krampera;Department of Biomedical Sciences,University of Ngaoundere;Laboratory,University of Verona;Department of Basic,Health Sciences,College of Applied Medical Sciences,Qassim University;Faculty of Science,University of Poitiers;Department of Biochemistry,College of Medicine,University of Saskatchewan;

【Institution】

Department of Biomedical Sciences,University of Ngaoundere;Laboratory,University of Verona;Department of Basic,Health Sciences,College of Applied Medical Sciences,Qassim University;Faculty of Science,University of Poitiers;Department of Biochemistry,College of Medicine,University of Saskatchewan;

【Abstract】

Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed.

【Keywords】

Cancer metastasis;;developmental pathways;;Notch;;Wnt;;Hedgehog;;therapeutic targets

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