Maintaining proton homeostasis is an essential role of the Warburg effect in proliferating cells

【Author】

Chuangzhen Yang;Binghui Li;Department of Biochemistry and Molecular Biology, Capital Medical University;Advanced Innovation Center for Human Brain Protection, Capital Medical University;Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University;

【Institution】

Department of Biochemistry and Molecular Biology, Capital Medical University;Advanced Innovation Center for Human Brain Protection, Capital Medical University;Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University;

【Abstract】

<正>Non-proliferating cells efficiently generate adenosine 5’-triphosphate (ATP) through mitochondrial oxidative phosphorylation.By contrast, proliferating cells, including cancer cells, tend to rely on aerobic glycolysis, an inefficient way to generate energy, and this phenomenon is termed "the Warburg effect"~(1,2).However, the advantage of the Warburg effect provided for proliferating cells has been unclear~3.Here we propose that aerobic glycolysis may maintain proton homeostasis to benefit proliferating cells.

【Keywords】

Maintaining proton homeostasis is an essential role of the Warburg effect in proliferating cells;

References

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Springer Journals Database

Total: 9 articles

  • [1] Miao Liu;Yuanyuan Wang;Yuxia Ruan;Changsen Bai;Li Qiu;Yanfen Cui;Guoguang Ying;Binghui Li;Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy;Tianjin's Clinical Research Center for Cancer;Department of Biochemistry and Molecular Biology, Capital Medical University;, PKM2 promotes reductive glutamine metabolism, Cancer Biology & Medicine,
  • [2] Binghui Li;;Gabriel M. Gordon;;Charles H. Du;;Jinhua Xu;;Wei Du, Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2, Cancer Cell,
  • [3] Valeria R. Fantin;;Julie St-Pierre;;Philip Leder, Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance, Cancer Cell,
  • [4] Francis P Kuhajda, Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology, Nutrition,

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