Tissue specificity of DNA damage response and tumorigenesis

【Author】

Siman Sun;Michael D.Osterman;Mo Li;Center for Reproductive Medicine, Peking University Third Hospital;Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital;School of Basic Medical Sciences, Peking University Health Science Center;Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine;

【Institution】

Center for Reproductive Medicine, Peking University Third Hospital;Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital;School of Basic Medical Sciences, Peking University Health Science Center;Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine;

【Abstract】

The genome of cells is constantly challenged by DNA damages from endogenous metabolism and environmental agents.These damages could potentially lead to genomic instability and thus to tumorigenesis.To cope with the threats, cells have evolved an intricate network, namely DNA damage response(DDR) system that senses and deals with the lesions of DNA.Although the DDR operates by relatively uniform principles, different tissues give rise to distinct types of DNA damages combined with high diversity of microenvironments across tissues.In this review, we discuss recent findings on specific DNA damage among different tissues as well as the main DNA repair way in corresponding microenvironments, highlighting tissue specificity of DDR and tumorigenesis.We hope the current review will provide further insights into molecular process of tumorigenesis and generate new strategies for cancer treatment.

【Keywords】

DNA damage response;;tissue specificity;;tumorigenesis;;microenvironment;;cancer treatment

References

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Springer Journals Database

Total: 79 articles

  • [1] Chien-Hsieh Chiang;Kuo-Chin Huang;Department of Family Medicine,National Taiwan University Hospital and College of Medicine;Department of Community and Family Medicine,National Taiwan University Hospital Yun-Lin Branch;Graduate Institute of Clinical Medical Science,China Medical University;, Association between metabolic factors and chronic hepatitis B virus infection, World Journal of Gastroenterology,
  • [2] Michael R. Lieber, The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway, Annual Review of Biochemistry,
  • [3] Aziz Sancar;Laura A. Lindsey-Boltz;Keziban Unsal-Kaccmaz;Stuart Linn, MOLECULAR MECHANISMS OF MAMMALIAN DNA REPAIR AND THE DNA DAMAGE CHECKPOINTS, Annual Review of Biochemistry,
  • [4] George-Lucian Moldovan;Alan D. D'Andrea, How the Fanconi Anemia Pathway Guards the Genome, Annual Review of Genetics,

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