Sex-determining region Y box-containing genes: regulators and biomarkers in gynecological cancers


Jiali Hu;Ke Li;Zhanghuan Li;Chao Gao;Fei Guo;Yingmei Wang;Fengxia Xue;Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital;


Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital;


Sex-determining region Y box-containing genes are transcription factors with roles in multiple biological processes, including cell differentiation, proliferation, and apoptosis.Sex-determining region Y box-containing genes have also been shown to act as regulators and biomarkers in the progression of many different cancers, including gynecological cancers such as ovarian, cervical,and endometrial cancer.In this review, we summarize the contrasting regulatory roles of Sex-determining region Y box-containing genes in different gynecological cancers, as promotors with high expression levels or as suppressors with low expression levels.Expression levels of Sex-determining region Y box-containing genes were also identified as biomarkers of clinical features, including International Federation of Gynecology and Obstetrics stage, histopathologic grade together with disease-free survival, and treatment efficacy in patients with gynecological cancers.An understanding of the mechanisms whereby Sex-determining region Y box-containing genes regulate the progression of gynecological cancers will aid in the development of novel diagnostic and therapeutic strategies, while analysis of Sex-determining region Y box-containing expression levels will help to predict the prognosis of patients with gynecological cancers.


Sex-determining region Y box-containing gene;;gynecological cancer;;regulator;;biomarker;;clinical feature;;progression


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  • [1] Armel Herve Nwabo Kamdje;Paul Takam Kamga;Richard Tagne Simo;Lorella Vecchio;Paul Faustin Seke Etet;Jean Marc Muller;Giulio Bassi;Erique Lukong;Raghuveera Kumar Goel;Jeremie Mbo Amvene;Mauro Krampera;Department of Biomedical Sciences,University of Ngaoundere;Laboratory,University of Verona;Department of Basic,Health Sciences,College of Applied Medical Sciences,Qassim University;Faculty of Science,University of Poitiers;Department of Biochemistry,College of Medicine,University of Saskatchewan;, Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog, Cancer Biology & Medicine,
  • [2] Robert L Hollis;Charlie Gourley;Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh;, Genetic and molecular changes in ovarian cancer, Cancer Biology & Medicine,
  • [3] Brett M.Reid;Jennifer B.Permuth;Thomas A.Sellers;Department of Cancer Epidemiology,Division of Population Sciences,Moffitt Cancer Center;, Epidemiology of ovarian cancer:a review, Cancer Biology & Medicine,
  • [4] Donal J. Brennan;;Sara Ek;;Emma Doyle;;Thomas Drew;;Michael Foley;;Grainne Flannelly;;Darran P. O’Connor;;William M. Gallagher;;Sami Kilpinen;;Olli-Pekka Kallioniemi;;Karin Jirstrom;;Colm O’Herlihy;;Carl A.K. Borrebaeck, The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer, European Journal of Cancer,


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