Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site

【Author】

Xi Wei;Meng Wang;Xiaoqing Wang;Xiangqian Zheng;Ying Li;Yi Pan;Yueguo Li;Jiali Mu;Yang Yu;Dapeng Li;Ming Gao;Sheng Zhang;Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;Department of Thyroid and Cervical Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;

【Institution】

Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;Department of Thyroid and Cervical Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy,Tianjin, Tianjin's Clinical Research Center for Cancer;

【Abstract】

Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis.Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed.We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models.The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status.Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement.In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node metastases.The cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients.

【Keywords】

Ultrasonography;;thyroid;;lymph nodes;;metastasis;;evaluation

References

To explore the background and basis of the node document

Springer Journals Database

Total: 11 articles

  • [1] Ming Gao;Minghua Ge;Qinghai Ji;Ruochuan Cheng;Hankui Lu;Haixia Guan;Wei Cui;Li Gao;Zairong Gao;Lin Guo;Zhuming Guo;Tao Huang;Xiaoming Huang;Yansong Lin;Qinjiang Liu;Xin Ni;Jianwu Qin;Li Ren;Zhongyan Shan;Hui Sun;Xudong Wang;Zhengang Xu;Yang Yu;Bin Zhang;Daiwei Zhao;Ying Zheng;Jingqiang Zhu;Xiangqian Zheng;Department of Head and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer;Department of Head and Neck, Zhejiang Cancer Hospital;Department of Head and Neck Tumor, Fudan University Shanghai Cancer Center;Department of General Surgery,First Affiliated Hospital of Kunming Medical University;Department of Nuclear Medicine, The Sixth Affiliated Hospital of Shanghai Jiao Tong University;Department of Endocrinology, The First Hospital of China Medical University;Department of Clinical Laboratory, Cancer Hospital Chinese Academy of Medical Science;Department of Head and Neck, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine;Department of Nuclear Medicine, Union Hospital Tongji Medical College Huazhong University of Science and Technology;Department of Clinical Laboratory, Fudan University Shanghai Cancer Center;Sun Yat-sen University Cancer Center;Department of Thyroid and Breast, Union Hospital Tongji Medical College Huazhong University of Science and Technology;Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University;Department of Nuclear Medicine, Peking Union Medical College Hospital;Department of Head and Neck, Gansu Provincial Cancer Hospital;Department of Head and Neck, Beijing Children’s Hospital, Capital Medical University;Department of Thyroid, Head and Neck, Henan Cancer Hospital;Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer;Department of Thyroid, Sino Japanese Union Hospital of Jilin University;Department of Head and Neck, Cancer Hospital Chinese Academy of Medical Sciences;Department of Head and Neck, Peking Union Medical College Hospital;Department of General Surgery, The Second Affiliated Hospital of Guizhou Medical University;Department of Head and Neck, Jilin Tumor Hospital;Department of Thyroid and Breast, West China School of Medicine, West China Hospital, Sichuan University;Chinese Association of Thyroid Oncology (CATO);China Anti-Cancer Association;, 2017 Chinese expert consensus on the clinical application of serum marker for thyroid cancer, Cancer Biology & Medicine,
  • [2] Andreas Machens;;Steffen Hauptmann;;Henning Dralle, Lymph node dissection in the lateral neck for completion in central node-positive papillary thyroid cancer, Surgery,
  • [3] Nimmi Arora;;Harma K. Turbendian;;Theresa Scognamiglio;;Patrick L. Wagner;;Stanley J. Goldsmith;;Rasa Zarnegar;;Thomas J. Fahey, Extrathyroidal extension is not all equal: Implications of macroscopic versus microscopic extent in papillary thyroid carcinoma, Surgery,
  • [4] M.R. Pelizzo;;I.M. Boschin;;A. Toniato;;A. Piotto;;P. Bernante;;C. Pagetta;;L. Rampin;;D. Rubello, Papillary thyroid microcarcinoma (PTMC): Prognostic factors, management and outcome in 403 patients, European Journal of Surgical Oncology,

More>>

Similar documents

Documents that have the similar content to the node document

  • [1] Patients with brain metastases from gastrointestinal tract cancer treated with whole brain radiation therapy:Prognostic factors and survival, World Journal of Gastroenterology, 2004 (22)
  • [2] The study on quantitative expression of CD44v6mRNA by real-time RT-PCR with the micro-metastases of gastric cancer, Journal of Nanjing Medical University, 2005 (06)
  • [3] Treatment for liver metastases from breast cancer: Results and prognostic factors, World Journal of Gastroenterology, 2005 (24)
  • [4] Dinesh Chandra Doval;Komal Bhatia;Ashok Kumar Vaid;Keechelat Pavithran;Jai Bhagwan Sharma;Digant Hazarika;Amarnath Jena;, Spinal cord compression secondary to bone metastases from hepatocellular carcinoma, World Journal of Gastroenterology, 2006 (32)

More>>