Dynamical Model of P53-Mdm2-P14/19ARF Network to Radiation in Population of Cells

【Author】

Hui Liu,Yingrong Han,Yafei Chen,Suhua Zhang,Tongjun Zhao,Yong Zhan Institute of Biophysics,Hebei University of Technology,Tianjin 300130,China

【Abstract】

From the recent experiments ofγradiation and models given before,we study the dynamical model of p53 and Mdm2 regulated by p14/19ARF in population of cells.In order to study how they infect the mechanism of the negative feedback loop,we give numerical results to study the oscillatory features of p53,Mdm2 and p14/19ARF in population of cells.The dynamical model and results will help us understand the oscillatory features of p53,Mdm2 and p14/19ARF to radiation in population of cells.

【Keywords】

p53,Mdm2,P14/19ARF,Dynamical Model

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