JSI-124 may induces apoptosis of leukaemia cells independent of JAK2/STAT3 pathway and compromise immune response

【Author】

Masengere H.;Miao M.;Luan Z.;Yu G.;

【Abstract】

<正>Objectives: Evaluate the effects of JSI-124 on leukemia cells and explore whether the expression of STAT3 and phospho-STAT3(pSTAT3) in tumor cells is related to their sensitivity to JSI-124, and further assess the effect of JSI-124 on the immune system. Methods: We examined the effects of JSI-124 on five leukemia cell lines. Dose and time-dependent

【Keywords】

apoptosis;JSI-124 may induces apoptosis of leukaemia cells independent of JAK2/STAT3 pathway and compromise immune response;JAK;

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