Structural insights into the mechanisms underlying eukaryotic gene regulation

【Author】

Joel Mackay;Roland Gamsjaeger;Sock Yue Thong;Saad AIQarni;Sarah Webb;Lorna Wilkinson-White;Sara Leion;Jacqui Matthews;Ernest Laue;Gerd Blobel;

【Abstract】

<正>The transcription factor GATA-1 plays an important role in the development of the erythroid and megakaryocytic cell lineages,and is one of the most intensively studied gene regulatory proteins.It is well established that GATA-1 binds to gene regulatory elements that contain GATA DNA sequences,and thereby ultimately regulates the expression of hundreds of genes involved in hematopoietic development.However,the steps between DNA binding and changes in the expression levels of target genes are

【Keywords】

gene;Structural insights into the mechanisms underlying eukaryotic gene regulation;

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