Learning eukaryotic signaling mechanisms from bacterial virulence factors

【Author】

Feng Shao;

【Abstract】

<正>Gram-negative pathogenic bacteria have evolved a specialized typeⅢsecretion system to inject effector proteins into host cells.These effectors attack and modulate host signal transduction pathways,thereby contributing to infection and disease onset/progression.We recently discovered two novel families of typeⅢeffectors defined by OspF from diarrhea-causing Shigella flexneri and CHBP from Melioidosis-causing Burkholderia pseudomallei,respectively.The OspF family, including SpvC from Salmonella and HopAI 1 from plant pathogen P.syringae,harbors

【Keywords】

Learning eukaryotic signaling mechanisms from bacterial virulence factors;MAPKs;

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