Two Cu(Ⅱ) Complexes with Hydrolyzed Nicotinamide Ligand: Crystal Structures and Bioactivities

【Author】

WANG Ren-Shu;FENG Jing;LIAN Ming-Lei;KONG De-Shun;LEI Yi-Zhu;SHI Kai-Yi;School of Chemistry and Materials Engineering, Liupanshui Normal University;

【Institution】

School of Chemistry and Materials Engineering, Liupanshui Normal University;

【Abstract】

Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H_2O)]·H_2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu_2(2,4-D)_4(Hnta)_2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA(ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA(pBR322-DNA) was determined by gel electrophoresis assay. And at last, the complexes' cytotoxic activities were reviewed for four kinds of cancer cell lines(HeLa, MCF-7, HepG, SKOV-3), showing that the coordination polymer has anti-tumor activity and cytotoxicity.

【Keywords】

Cu(Ⅱ) complexes;;Hirshfeld surface analysis;;crystal structures;;bioactivities

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Total: 31 articles

  • [1] YANG Ying-Qun,1,2 CHEN Zhi-Min1 KUANG Yun-Fei1(1Department of Chemistry and Materials Science,Hengyang Normal University,Hengyang,Hunan 421008,China)(2Hengyang Xicheng Organic Chemical Plant,Hengyang,Hunan 421008,China), Synthesis,Crystal Structure and Properties of a Trinuclear Zinc(Ⅱ) Complex Constructed by 2,4-Dichlorophenoxyacetate, Chinese Journal of Inorganic Chemistry,
  • [2] WANG Ren-Shu;FENG Jing;LEI Yi-Zhu;YANG Dang;ZHU Ming-Chang;XING Jia-Ling;LIAN Ming-Lei;School of Chemistry and Materials Engineering, Liupanshui Normal University;Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology;, Crystal Structure and Bioactivities of Mn(Ⅱ)Coordination Polymer with Biological Ligand of 2-Quinolinecarboxylic-carboxylate, Chinese Journal of Inorganic Chemistry,
  • [3] Victoria L Singer;;Timothy E Lawlor;;Stephen Yue, Comparison of SYBR? Green I nucleic acid gel stain mutagenicity and ethidium bromide mutagenicity in the Salmonella /mammalian microsome reverse mutation assay (Ames test), Mut.Res.-Genetic Toxicology and Environmental Mutagenesis,
  • [4] Junhua Luo;;Feilong Jiang;;Ruihu Wang;;Lei Han;;Zhenzhong Lin;;Rong Cao;;Maochun Hong, Self assembly of a 2D bilayer Cd(II)-organic framework with mixed nicotinate/dicyanoamide ligands, Journal of Molecular Structure,

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