WANG Ren-Shu;FENG Jing;LIAN Ming-Lei;KONG De-Shun;LEI Yi-Zhu;SHI Kai-Yi;School of Chemistry and Materials Engineering, Liupanshui Normal University;
School of Chemistry and Materials Engineering, Liupanshui Normal University;
Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(H_2O)]·H_2O(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu_2(2,4-D)_4(Hnta)_2](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA(ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA(pBR322-DNA) was determined by gel electrophoresis assay. And at last, the complexes' cytotoxic activities were reviewed for four kinds of cancer cell lines(HeLa, MCF-7, HepG, SKOV-3), showing that the coordination polymer has anti-tumor activity and cytotoxicity.
Cu(Ⅱ) complexes;;Hirshfeld surface analysis;;crystal structures;;bioactivities
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