Study on Synthesis of(R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazo lidine-3-carboxylate

【Author】

Cheng Liang;Shuanglin Qin;Xiaoji Wang;Shuangping Huang;

【Abstract】

(R)-tert-butyl 2,2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate,an key intermediate of Biotin which is a water-soluble vitamin involved in an essential part of the metabolic cyle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids,sugars,and α-amino acids,was synthesized from L-cystine in overall yield 41% through six steps,which included esterification,Boc protection,acetonization,reduction,Corey-Fuchs reaction.

【Keywords】

(R)-tert-butyl 2;;2-dimethyl-4-(prop-1-yn-1-yl)oxazolidine-3-carboxylate;;Biotin;;L-serine;;synthesis

References

To explore the background and basis of the node document

Springer Journals Database

Total: 5 articles

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