Ubiquitination of NO-Synthase:Role of hsp90 and hsp70 chaperones

【Author】

Yoichi Osawa;Hwei-Ming Peng;

【Abstract】

<正>It is widely thought that drug-derived reactive intermediates,which are often generated by cytochrome P450 enzymes,cause toxicity,in part,by covalently altering cellular proteins.One of the initial targets of these reactive intermediates is the cytochrome P450 itself and this can lead to the covalent alteration,inactivation,and proteolytic removal of the enzyme.In order to better

【Keywords】

Ubiquitination of NO-Synthase;

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