Preparation and Property of PDA/CPP Bilayer on SLA Surfaces

【Author】

ZHANG Jia-Min;WANG Tao;TANG Chun-Bo;WANG Qiao-Na;QIAN Hai-Mei;MIAO Run-Jie

【Institution】

College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics;College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics;Stomatological Hospital of Jiangsu Province;Stomatological Hospital of Jiangsu Province;College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics;College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics

【Abstract】

A polydopamine/casein phosphopeptides (PDA/CPP) bilayer was prepared on the pure titanium surface with macro and micro pits formed by sandblasting with large-grit and acid-etching (SLA). The PDA interlayer with extraordinary adhesion and the capability of second functional modification, linked CPP, the natural biomolecules, to the SLA titanium surface via covalent bonds. This two-step immersion modification process was simple and feasible. Field emission scanning electronic microscope (FESEM), energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscppe (XPS) were utilized to analyze microtopography and elementary composition of PDA/CPP bilayer. Contact angle analysis, biomimetic mineralization examinations and human bone marrow stem cells (hBMSCs) experiments in vitro were conducted to verify the biocompatibility of the modified surfaces. The results showed that the PDA/CPP bilayer was successfully grafted onto the SLA substrates through the two-step immersion method. The bilayer decreased the contact angle of SLA with pure water from 47.7° to 25.5°, showing the improved hydrophilicity obviously. Compact hydroxyapatite (HA) layer was formed after SLA/PDA/CPP immersed in simulated body fluid (SBF) for 1 d, demonstrating that the bilayer accelerated the rate of biomineralization significantly. Besides, the PDA/CPP bilayer efficiently enhanced the cell attachment, cell proliferation and cell mineralization.

【Keywords】

polydopamine;casein phosphopeptides;SLA;pure titanium;bio-activation

References

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Total: 22 articles

  • [1] WANG Hai\|jie 1* , TAN Yu\|zhen\+2 (1 Department of Anatomy; 2.Department of Histology and Embryology,Shanghai Medical University,Shanghai\ 200032,China) [, THE DISTRIBUTION OF ACTIN AND THE LEVEL OF Ca ~(2+ ) IN THE ACTIVATED MACROPHAGES, Acta Anatomica Sinica,
  • [2] Fu Yanyan,Song Yueqing~*,Hui Songxiao,Mi Xujun(State Key Laboratory for Fabrication &(Processing) of Non-Ferrous Metals,General Research Institute for Non-Ferrous Metals,Beijing 100088,China), Research and Application of Typical Aerospace Titanium Alloys, Chinese Journal of Rare Metals,
  • [3] LIU Shi-min1,2,ZHOU Yu1(1 School of Material Science and Engineering,Tianjin University,Tianjin 300072,China;2 Business School,Tianjin University of Commerce,Tianjin 300134,China), Study on Development and Tendency of Bioactive Coatings on Titanium Alloys Surface, Journal of Materials Engineering,
  • [4] DONG Fei, DING Zhong-juan, NIU Tao. (Dept. of Prosthodontics, College of Stomatology, Kunming University of Medical Sciences, Kunming 650031, China), Effects of TiO_2 blasted and acid-etched titanium surfaces on oxide-film and osteoblast, West China Journal of Stomatology,

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