Core-shell Structured Hydroxyapatite/Mesoporous Silica Nanoparticle: Preparation and Application in Drug Delivery


SONG Jing-Jing;CHEN Bo;LIN Kai-Li


School of Chemistry and Molecular Engineering, East China Normal University;School of Chemistry and Molecular Engineering, East China Normal University;Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School & Hospital of Stomatology, Tongji University


Core-shell nanoparticle is a kind of composite nanomaterials with unique structure and properties, which has important application prospects in the fields of catalysis, biomedicine, photonic crystal, etc. A new kind of materials, core-shell structured HAp@mSiO 2 nanoparticles with mesoporous structure were prepared by improved St?ber coating method using hydroxyapatite (HAp) nanoparticles as core and cetyltrimethylammonium bromide (CTAB) as mesoporous template. By controlling the concentration of tetraethyl orthosilicate (TEOS) and its hydrolysis and condensation kinetics, the thickness of mSiO 2 shell coating on the core HAp surface could be well regulated. The results of TEM, EDS, XRD, FT-IR, and BET testing show that the prepared HAp@mSiO 2 nanoparticles have the characteristics of high specific surface area, narrow pore size and uniform distribution. And using the Ibuprofen as model drug, the prepared materials were tested for drug adsorption and release experiments. It is found that the obtained core-shell structured materials also have good drug control properties and pH response characteristics, and can effectively control the drug release rate and release amount through altering the mSiO 2 shell thickness.


core-shell structure;hydroxyapatite;mesoporous silica;drug release;pH response


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Total: 29 articles

  • [1] HAO Li-Jing,YANG Hui,ZHAO Na-Ru,WANG Ying-Jun(Nation Engineering Research Center for Tissue Restoration and Reconstruction,College of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,China), Hydrothermal Synthesis of Hydroxyapatite Fibers Precipitated by Propionmide, Journal of Inorganic Materials,
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  • [3] QI Mei-Li;QI Jia;XIAO Gui-Yong;LV Yu-Peng;Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials,Ministry of Education,Shandong University;School of Materials Science and Engineering,Shandong University;Shandong University Suzhou Institute;, Effect of Surfactants on the Morphology of Hydroxyapatite Fibers, Journal of Inorganic Materials,
  • [4] ZHI Wei;SHI Feng;LI Jing-Yu;ZHOU Teng;QU Shu-Xin;WANG Jian-Xin;ZHANG Cong;WENG Jie;Key Laboratory of Advanced Technologies of Materials (Ministry of Education),School of Materials Science and Engineering,Southwest Jiaotong University;The 309st Hospital of Chinese PLA;, Surface Microstructure on Hydroxyapatite Spherules and Its Regulation on Stem Cells, Journal of Inorganic Materials,