SONG Jing-Jing;CHEN Bo;LIN Kai-Li
School of Chemistry and Molecular Engineering, East China Normal University;School of Chemistry and Molecular Engineering, East China Normal University;Shanghai Engineering Research Center of Tooth Restoration and Regeneration, School & Hospital of Stomatology, Tongji University
Core-shell nanoparticle is a kind of composite nanomaterials with unique structure and properties, which has important application prospects in the fields of catalysis, biomedicine, photonic crystal, etc. A new kind of materials, core-shell structured HAp@mSiO 2 nanoparticles with mesoporous structure were prepared by improved St?ber coating method using hydroxyapatite (HAp) nanoparticles as core and cetyltrimethylammonium bromide (CTAB) as mesoporous template. By controlling the concentration of tetraethyl orthosilicate (TEOS) and its hydrolysis and condensation kinetics, the thickness of mSiO 2 shell coating on the core HAp surface could be well regulated. The results of TEM, EDS, XRD, FT-IR, and BET testing show that the prepared HAp@mSiO 2 nanoparticles have the characteristics of high specific surface area, narrow pore size and uniform distribution. And using the Ibuprofen as model drug, the prepared materials were tested for drug adsorption and release experiments. It is found that the obtained core-shell structured materials also have good drug control properties and pH response characteristics, and can effectively control the drug release rate and release amount through altering the mSiO 2 shell thickness.
core-shell structure;hydroxyapatite;mesoporous silica;drug release;pH response
To explore the background and basis of the node document