Exploring the novel enzyme functions by molecular evolution

【Author】

Yan Feng;Anarul Hoque;Guangyu Yang;Yu Zhang;Yong Zhang;Li Cui;

【Abstract】

<正>Synthetic organophosphate(OP)compounds are highly toxic due to their irreversible inhibition of central nervous system acetylcholinesterase in all vertebrates.The continuous and excessive use of OP compounds as agricultural pesticides has led to the contamination of many terrestrial and aquatic ecosystems.Enzymatic degradation of OP compounds has received considerable attention because it provides the possibility of both environmentally friendly and in situ detoxification.The phosphotriesterase

【Keywords】

pesticides;contamination;agricultural;irreversible;friendly;terrestrial;possibility;aquatic;targeted;evolutionary;

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