Dissecting the roles of enzymes and regulatory elements in nosiheptide biosynthesis

【Author】

Yijun Chen;

【Abstract】

<正>Nosiheptide,a secondary metabolite of Streptomyces actuosus ATCC 25421,possesses strong activities against gram-positive bacterial pathogens and has been used as a feed additive.Similar to other thiopeptides,the biosynthetic pathway of nosiheptide was uncovered to be a ribosomally-synthesized and post-translationally modified peptide(RiPP)system.Thus far,the roles of a very limited number of genes responsible for different modifications have been identified among the 16-gene cluster.In our continuous

【Keywords】

metabolite;biosynthesis;additive;maturation;activating;enzymes;necessity;conserved;elucidation;residues;

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