Versatile peptide C-terminal functionalization via computationally engineered peptide amidase

【Author】

Bian Wu;

【Abstract】

<正>The bioactivity of synthetic peptides,including potency,stability and bioavailability,are strongly influenced by modification of the peptide chain termini.Unfortunately,generally applicable methods for selective and mild C-terminal peptide functionalization are lacking.In this work,we explored the peptide amidase from Stenotrophomonas maltophilia as a versatile catalyst for diverse carboxy-terminal peptide

【Keywords】

termini;carboxy;engineered;diverse;bioactivity;versatile;lacking;ammonia;applicable;robustness;

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