Modulation of conformational dynamics of an enzyme for relieving product inhibition

【Author】

Hak-Sung Kim;

【Abstract】

<正>Protein dynamics play a crucial role in enzyme catalysis,influencing the mechanistic steps during the catalysis.An understanding of the interplay between the conformational dynamics and each mechanistic event will provide crucial insight into the design of enzymes with the desired catalytic property.Despite many advances in the fundamental aspects of the protein dynamics,however,a practical implementation of such knowledge to the design of enzymes remains a challenge.In this talk,I will present the engineering of

【Keywords】

conformational;catalysis;desired;insight;advances;steps;challenge;enzymes;pyruvate;diverse;

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