Microbial bioconversion:an efficient tool for production of diverse value-added industrial compounds from fatty acid

【Author】

Hak-Ryul Kim;In-Hae Choi;Hyung-Geun Lee;Qi Long;Chakradhar Dasagrandhi;Ching T.Hou;

【Abstract】

Structural modification of natural lipids via chemical reaction or microbial bioconversion can change their properties or even create novel functionalities.Enzymatic oxidation of lipids leading to formation of oxylipin is one of those modifications.Hydroxy fatty acids,one of those oxylipins have gained important attentions because of their structural and functional properties compared with other non-hydroxy fatty acids.Recently 7,10-dihydroxy-8(E)-octadecenoic acid(DOD)was produced with high yield from lipid containing oleic acid by bacterial strain Pseudomonas aeruginosa PR3,and further study confirmed that DOD contained strong antimicrobial activities against broad range of microorganisms.In this study we tried to modify DOD molecules by enzymatic or physical reaction to create new functionality or to enhance the antimicrobial activity of DOD.After modification of DOD molecules by different ways,we confirmed that the antimicrobial activity of DOD was highly enhanced,suggesting that DOD and its derivatives could be used as an efficient antimicrobial agent for industrial applications.

【Keywords】

antimicrobial;lipids;dihydroxy;diverse;oleic;contained;functionality;enzymatic;tried;gained;

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