The tumor-specific intrabody against cyclin-dependent kinase(CDK) 4 inhibits proliferation and migration of breast cancer cells

【Author】

Xiangzhi Liao;Ying Zhang;Xun Zhou;Luwei Huang;Chuanxi Fan;Weiwei Tang;An Cui;Haipeng Miao;Ying Xue;Jialiang Zhao;Liangzhong Zhao;Guiying Li;

【Abstract】

<正>Introduction Breast cancer is the most common cancer among women both in the developed and the developing world.The incidence of breast cancer is increasing in the developing world.There is a compelling need for novel strategy that will improve the treatment of breast cancer.Cyclin-dependent kinase(CDK)4 is a positive regulator of cell cycle entry and it is overactive in the majority of human cancers including breast

【Keywords】

migration;CDK;Cyclin;regulator;cycle;majority;incidence;inhibited;scFv;cytometry;

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