Identification of an imine reductase for efficient asymmetric reduction of bulky dihydroisoquinolines

【Author】

Hao Li;Gao-Wei Zheng;Jian-He Xu;

【Abstract】

<正>Chiral amines are important building blocks widely demanded for numerous biological active pharmaceutical drugs,natural products and fine chemicals in organic synthesis.Among them,optically pure tetrahydroisoquinoline(THIQ)structure motifs are existed in many valuable natural alkaloids with exquisite biological activity and pharmaceutical properties.For example,1-methyl-1,2,3,4-THIQ(1-Me THIQ)with parkinsonism-preventing effect,salsolidine with inhibition effect of monoamine oxidase and

【Keywords】

pharmaceutical;chemicals;numerous;alkaloids;imine;asymmetric;blocks;amines;valuable;demanded;

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