Efficient Synthesis of tert-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate by a newly identified carbonyl reductase from Lactobacillus brevis

【Author】

Xu-Min Gong;Gao-Wei Zheng;Jian-He Xu;

【Abstract】

<正>Atorvastatin,the active ingredient of Lipitor,was the top selling cholesterol-lowering drug in the world.Like with other statins,it contains a 3,5-dihydroxyhexanoate side chain,the key pharmacophore of the molecule.Making the side chain is challenging because it has two chiral centers,and greater than 99.5%enantiomeric and 99%diastereomeric excess are required.

【Keywords】

cyano;carbonyl;challenging;brevis;ingredient;lowering;chiral;Lactobacillus;selling;butyl;

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