Evolution of ornithine decarboxylase with promiscuous substrate specificity

【Author】

Kwan-Jib Kim;Jin-Young Lee;Hyang Choi;Hak-Sung Kim;

【Abstract】

<正>Ornithine decarboxylase(ODC,EC 4.1.1.17),lysine decarboxylase(LDC,EC 4.1.1.18),and arginine decarboxylase(ADC,EC 4.1.1.19)are pyridoxal 5'-phosphate(PLP)-based family enzymes which catalyze the decarboxylation of ornithine,lysine and arginine,respectively.These enzymes are thought to be divergently evolved from a common ancestor because of their substrate promiscuity.Here,we identified the

【Keywords】

decarboxylase;ornithine;arginine;lysine;evolved;specificity;catalyze;enzymes;alignment;mutant;

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