The role of radiotherapy in 74 patients with dermatofibrosarcoma protuberans

【Author】

Xiushen Wang1,Mengzhong Liu2,Hui Liu2,Nianji Cui2 1 Department of Radiotherapy,Cancer Hospital of Henan Province,Zhengzhou 450008,China 2 Department of Radiotherapy,Cancer Hospital,Sun Yat-sen University,Guangzhou 510060,China

【Abstract】

Objective:To study treatment and prognostic factor in 74 patients with dermatofibrosarcoma protuberans.Meth-ods:From August 1990 to November 1999,74 patients with dermatofibrosarcoma protuberans(DFSP)confirmed by pathology were treated in Cancer Hospital of Sun Yat-sen University.72 cases were given wide excision and 2 cases were given local exci-sion.All of 74 cases,52 cases had surgical resection alone,and 22 cases had surgical resection combined with radiotherapy.Total dose of radiotherapy was 50-70 Gy.Results:The rate of recurrence was 36.1% for all patients.The 5-year recurrence-free survival(RFS)rate was 66%.The 5-year recurrence-free survival rates for resection alone and combined with radiotherapy were 58% and 90%,respectively(P=0.0187).The 5-year recurrence-free survival rates for positive microscopic margins and negative microscopic margins were 57% and 75%,respectively(P=0.0468).Conclusion:Post-operation radiotherapy is an effective treatment to decrease the recurrence rate for the patients with positive microscope,or the patients without suitable surgical treatment.

【Keywords】

dermatofibrosarcoma protuberans(DFSP);radiotherapy;wide excision

References

To explore the background and basis of the node document

Springer Journals Database

Total: 12 articles

  • [1] Bowne WB;Antonescu CR;Leung DH,et al, Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and fol-lowed at a single institution, Cancer, Cancer (Cancer)
  • [2] Ding J;Hashimoto H;Enjoji M,et al, Dermatofibrosarcoma protuberans with fibrosarcomatous areasA clinicopathologic study of nine cases and a comparison with allied tumors, Cancer, Cancer (Cancer)
  • [3] Haas RL;Keus RB;Loftus BM,et al, The role of radiotherapy in the local management of dermatofibrosarcoma protuberans, Eur J Cancer, European Journal of Cancer (European Journal of Cancer)
  • [4] Mentzel T;Beham A;Katenkamp D,et al, Fibrosarcomatous (high-grade) dermatofibrosarcoma protuberans: clinicopathologic and im-munohistochemical study of a series of 41 cases with emphasis on prognostic significance, Am J Surg Pathol, The American Journal of Surgical Pathology (The American Journal of Surgical Pathology)

More>>

Similar documents

Documents that have the similar content to the node document

Springer Journals Database

Total: 49 articles

More>>