The role of radiotherapy in 74 patients with dermatofibrosarcoma protuberans


Xiushen Wang1,Mengzhong Liu2,Hui Liu2,Nianji Cui2 1 Department of Radiotherapy,Cancer Hospital of Henan Province,Zhengzhou 450008,China 2 Department of Radiotherapy,Cancer Hospital,Sun Yat-sen University,Guangzhou 510060,China


Objective:To study treatment and prognostic factor in 74 patients with dermatofibrosarcoma protuberans.Meth-ods:From August 1990 to November 1999,74 patients with dermatofibrosarcoma protuberans(DFSP)confirmed by pathology were treated in Cancer Hospital of Sun Yat-sen University.72 cases were given wide excision and 2 cases were given local exci-sion.All of 74 cases,52 cases had surgical resection alone,and 22 cases had surgical resection combined with radiotherapy.Total dose of radiotherapy was 50-70 Gy.Results:The rate of recurrence was 36.1% for all patients.The 5-year recurrence-free survival(RFS)rate was 66%.The 5-year recurrence-free survival rates for resection alone and combined with radiotherapy were 58% and 90%,respectively(P=0.0187).The 5-year recurrence-free survival rates for positive microscopic margins and negative microscopic margins were 57% and 75%,respectively(P=0.0468).Conclusion:Post-operation radiotherapy is an effective treatment to decrease the recurrence rate for the patients with positive microscope,or the patients without suitable surgical treatment.


dermatofibrosarcoma protuberans(DFSP);radiotherapy;wide excision


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