Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer

【Author】

Fei Gao;Lin Jia;Jianjun Han;Jisheng Wang;Yun Wang;Department of Oncology, The Third Hospital of Mianyang,Sichuan Mental Health Center;Department of Pharmacy, The Third Hospital of Mianyang,Sichuan Mental Health Center;

【Institution】

Department of Oncology, The Third Hospital of Mianyang,Sichuan Mental Health Center;Department of Pharmacy, The Third Hospital of Mianyang,Sichuan Mental Health Center;

【Abstract】

Objective To investigate variation in levels of transforming growth factor beta 1(TGF-β1)before and after radiotherapy in patients with esophageal cancer in order to evaluate the predictive value of TGF-β1 for the effects of radiotherapy Methods A total of 140 patients with esophageal squamous carcinoma undergoing radical radiation therapy in the Department of Oncology from March 2015 to December 2017 were enrolled.The patients were divided into the effective(115 cases)and ineffective(25 cases)groups according to World Health Organization(WHO)criteria for the evaluation of solid tumors(2009 RECIST standard).TGF-β1 levels were measured in all patients by using enzyme-linked immunosorbent assay(ELISA).Multiple-factor analysis of the predictive value of the treatment efficacy was performed by Cox regression analysis.Results After radiotherapy,36,79,and 25 cases experienced complete response(CR),partial response(PR),and no response(NR),respectively,with a total effective rate of 82.14%.The TGF-β1 level was significantly lower in the effective group than that in the ineffective group(P<0.05)and covariance analysis revealed significantly reduced TGF-β1 level in esophageal cancer patients following radiotherapy.The multi-factor Cox regression model revealed that the predictive value of TGF-β1 for the effect of radiotherapy was largest,with a hazard ratio[HR]of 1.955(P=0.002),followed by exposure dose,with(HR=1.367;P=0.035).Conclusion Serum TGF-β1 level can serve as a predictor for the short-term effects of radiotherapy in patients with esophageal cancer.

【Keywords】

transforming growth factor-β;;esophagus cancer;;radiotherapy;;short-term efficacy;;prediction

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Total: 16 articles

  • [1] LIU Yang;WANG Kunlun;YUAN Ling;Department of Radiation Oncology,the Affiliated Tumor Hospital,Zhengzhou University;, Curative effect analysis of 191 cases of esophageal carcinoma patients treated by radical radiotherapy, Journal of Zhengzhou University(Medical Sciences),
  • [2] Luo Hesan;Xu Hongyao;Li Yixuan;Wu Shengxi;Huang Hecheng;Lin Lianxing;Department of Radiation Oncology,Shantou Central Hospital;, Comparison of clinical effect between radiotherapy and chemoradiotherapy and analysis of the prognostic factors in 229 elderly patients with esophageal squamous cell cancer, Chongqing Medicine,
  • [3] Zhihao HUANG;Luxing ZHONG;Jiangxi Medical School of Nanchang University;Department of Oncology, the First Affiliated Hospital of Nanchang University;, Research progress on radiotherapy of esophageal carcinoma, Chinese Journal of Clinical Oncology,
  • [4] Jo-Anne de la Mare;;Tamarin Jurgens;;Adrienne L. Edkins, Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model, BMC Cancer,

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