Correlation between miR-564, TGF-β1, and radiation-induced lung injury

【Author】

Yunzhang Ge;Tao Xie;Bin Yang;Qianxia Li;Qingrong Ren;Xiaoyi Zhou;Desheng Hu;Zhongshu Tu;Hubei Province Tongcheng County Hospital of Traditional Chinese Medicine;Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hu Bei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment;Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;

【Institution】

Hubei Province Tongcheng County Hospital of Traditional Chinese Medicine;Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hu Bei Key Laboratory of Medical Information Analysis and Tumor Diagnosis & Treatment;Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;

【Abstract】

Objective Our study aimed to analyze the expression of mi R-564 and TGF-β1 in cancer tissues and the serum of patients with radiation-induced lung injury, and to investigate the relationship between them and radiation-induced lung injury. Methods In situ hybridization and real-time fluorescence quantitative method were used to detect the expression of mi R-564. Additionally, immunohistochemistry and enzyme-linked immunosorbent assay(ELISA) were performed to detect the expression of TGF-β1. Results The overall incidence of acute radiation pneumonia was 55.9%(100/179). The incidence of ≥ grade 2 radioactive pneumonia was 24.0%(43/179) and that of grade 1 was 31.8%(57/179). The expression of mi R-564 in grade ≥ 2 was slightly higher than that in patients without or with grade 1, but there was no statistical difference(P = 0.86). The serum level and ratio of mi R-564 in patients with grade ≥ 2 were significantly higher than those without or with grade 1(P = 0.005, P = 0.025, respectively). The expression of TGF-β1 in grade ≥ 2 was significantly higher than that of patients without or with grade 1(P = 0.017). The serum levels of TGF-β1 in grade ≥ 2 were significantly higher than those in patients without or with grade 1(P = 0.038). Although the ratio of TGF-β1 in radiation pneumonia of grade ≥ 2 was significantly higher than that of without or with grade 1, there was no significant difference(P = 0.24). Moreover, patients with higher expression of mi R-564 and lower expression of TGF-β1 had better prognosis.Conclusion Mi R-564 and TGF-β1 are predictors of radiation-induced lung injury. Monitoring its changing trend can improve the accuracy of predicting radiation-induced lung injury. The levels and ratio of serum mi R-564 and TGF-β1 in patients with radiation-induced lung injury are related to the severity of radiationinduced lung injury.

【Keywords】

radiation-induced lung injury;;miR-564;;TGF-β1

References

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Total: 10 articles

  • [1] Fei Gao;Lin Jia;Jianjun Han;Jisheng Wang;Yun Wang;Department of Oncology, The Third Hospital of Mianyang,Sichuan Mental Health Center;Department of Pharmacy, The Third Hospital of Mianyang,Sichuan Mental Health Center;, Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer, Oncology and Translational Medicine,
  • [2] Monika Chabicovsky;;Ute Wastl;;Henryk Taper;;Bettina Grasl-Kraupp;;Rolf Schulte-Hermann;;Wilfried Bursch, Induction of apoptosis in mouse liver adenoma and carcinoma in vivo by transforming growth factor-β1, Journal of Cancer Research and Clinical Oncology,
  • [3] Nian-Hua Ding;;Jian Jian Li;;Lun-Quan Sun, Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis, Current Drug Targets,
  • [4] Charito Love;;Christopher J. Palestro, Radionuclide Imaging of Inflammation and Infection in the Acute Care Setting, Seminars in Nuclear Medicine,

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