Clinical significance of S100A7 protein in predicting recurrence of breast cancer in patients undergoing breast-conserving surgery with radiotherapy

【Author】

Chao Zhang;Changyou Li;Gaoyang Lin;Yao Qi;Zhenfeng Li;Jing Xu;Tianhui Su;Xin Liu;Xiao Zou;Department of Medicine, Qingdao University;Biotherapy Center, The Second Affiliated Hospital of Qingdao University;Department of Thoracic Surgery, The Affiliated Qingdao Hiser Medical Center of Qingdao University;Department of Pathology, The Second Affiliated Hospital of Qingdao University;Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University;

【Institution】

Department of Medicine, Qingdao University;Biotherapy Center, The Second Affiliated Hospital of Qingdao University;Department of Thoracic Surgery, The Affiliated Qingdao Hiser Medical Center of Qingdao University;Department of Pathology, The Second Affiliated Hospital of Qingdao University;Department of Breast Surgery, The Second Affiliated Hospital of Qingdao University;

【Abstract】

Objective To investigate the relationship between the expression of S100 A7 protein and prediction of recurrence and prognosis of breast cancer in patients undergoing breast-conserving surgery combined with radiotherapy.Methods 349 samples of carcinoma tissue wax blocks were selected from January 2011 to January 2014 in Qingdao Central Hospital. All the patients had undergone breast-conserving surgery. We analyzed S100 A7 expression in tumor tissue by immunohistochemical staining. Using univariate and multivariate analyses, we evaluated the relationship between S100 A7 and clinical results, to explore independent risk factors for local regional recurrence(LRR). Results The positive expression of S100 A7 in the recurrence group(66.7%) was significantly higher than in the non-recurrence group(38.4%), P = 0.025. A log-rank test showed that high S100 A7 expression was significantly correlated with 5-year regional recurrence free survival rate(RFS)(94.9% vs 89.5%, P = 0.0408), distant metastasis free survival rate(DFS)(95.4% vs 83.5%, P < 0.001), and overall survival rate(OS)(99.0% vs 92.5%, P = 0.0011). Histological grade, vessel carcinoma embolus, lymph node metastasis, S100 A7 expression, and tumor size were factors that influenced RFS. Multivariate analysis of the Cox proportional hazard model showed that high S100 A7 expression was an independent risk factor that affected breast cancer RFS(HR = 6.864, 95 % CI: 1.575-29.915, P = 0.01). Thus, we concluded that high S100 A7 expression is associated with increased risk of LRR and distant metastasis of breast cancer after breast-conserving surgery and postoperative radiotherapy. S100 A7 can be used as a molecular marker to screen for patients with high recurrence risk after breast-conserving surgery.

【Keywords】

S100A7;;breast-conserving surgery;;radiotherapy;;locoregional recurrence;;prognosis

References

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Springer Journals Database

Total: 12 articles

  • [1] Age remains the first prognostic factor for loco-regional breast cancer recurrence in young (<40 years) women treated with breast conserving surgery first, Radiotherapy and Oncology,
  • [2] Hammond, M Elizabeth H;Hayes, Daniel F;Dowsett, Mitch;Allred, D Craig;Hagerty, Karen L;Badve, Sunil;Fitzgibbons, Patrick L;Francis, Glenn;Goldstein, Neil S;Hayes, Malcolm;Hicks, David G;Lester, Susan;Love, Richard;Mangu, Pamela B;McShane, Lisa;Miller, Keith;Osborne, C Kent;Paik, Soonmyung;Perlmutter, Jane;Rhodes, Anthony;Sasano, Hironobu;Schwartz, Jared N;Sweep, Fred C G;Taube, Sheila;Torlakovic, Emina Emilia;Valenstein, Paul;Viale, Giuseppe;Visscher, Daniel;Wheeler, Thomas;Williams, R Bruce;Wittliff, James, American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer (Unabridged Version), Archives of Pathology & Laboratory Medicine,
  • [3] Patrizia Cancemi;;Gianluca Di Cara;;Nadia Ninfa Albanese;;Francesca Costantini;;Maria Rita Marabeti;;Rosa Musso;;Ignazio Riili;;Carmelo Lupo;;Elena Roz;;Ida Pucci‐Minafra, Differential occurrence of S 100 A 7 in breast cancer tissues: A proteomic‐based investigation, Prot. Clin. Appl.,
  • [4] Jinjing Jia;;Qiqi Duan;;Jiaqi Guo;;Yan Zheng, Psoriasin, A Multifunctional Player in Different Diseases, Current Protein & Peptide Science,

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