Determining the efficacy of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis

【Author】

Yindi Tian;Ya Guo;Yue Ke;Yuyan Guo;Pengtao Yang;Hongbing Ma;Baofeng Wang;Department of Infectious Diseases, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University;Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University;

【Institution】

Department of Infectious Diseases, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University;Department of Radiation Therapy, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University;

【Abstract】

Objective This study aimed to investigate the effects of vitamin B12 mixed oral liquid in the treatment of radiation-induced esophagitis in patients with esophageal cancer.Methods Seventy-five patients with esophageal cancer who met the enrollment criteria were randomly divided into the vitamin B12 mixed oral liquid group(39 patients in the study group) and the gentamicin mixed oral liquid group(36 patients in the control group). The effects of the two treatment methods on esophagitis grading, pain degree, body weight loss, and Karnofsky performance status(KPS) score in patients with radiation esophagitis were observed.Results In the control group, grade 1 radiation esophagitis accounted for 27.8% of the total patients, grade 2 accounted for 41.7%, and grades 3 and 4 accounted for 30.6%. In the vitamin B12 treatment group, grade 1 radiation esophagitis accounted for 66.7% of the total patients, grade 2 accounted for 25.6%, and grades 3 and 4 accounted for 7.7%; there was a significant difference between the vitamin B12 treatment group and control group(P < 0.01). Similarly, pain caused by radiation esophagitis was significantly improved in the vitamin B12 group compared with the control group(P < 0.05). After treatment, the average weight loss of the control group was(2.18 ± 0.36) kg, while that of the vitamin B12 treatment group was(0.90 ± 0.43) kg(P < 0.05). The KPS scores of the vitamin B12 group were higher than those of the control group, which were 86.2 ± 1.2 and 85.6 ± 1.5, respectively, but there was no statistical difference(P > 0.05).Conclusion Vitamin B12 mixed oral liquid can effectively reduce the severity of radiation esophagitis, relieve pain, improve patients' quality of life, and increase treatment compliance.

【Keywords】

esophagitis;;vitamin B12;;quality of life;;Karnofsky performance status(KPS)

References

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Springer Journals Database

Total: 11 articles

  • [1] CHEN Xiang-long, SHI Yu-sheng Center of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China, Effect of vitamine B12 mixed solution inhalation for acute radiation-induced mucosal injury, Journal of Southern Medical University,
  • [2] Fei Gao;Lin Jia;Jianjun Han;Jisheng Wang;Yun Wang;Department of Oncology, The Third Hospital of Mianyang,Sichuan Mental Health Center;Department of Pharmacy, The Third Hospital of Mianyang,Sichuan Mental Health Center;, Predictive value of serum levels of transforming growth factor beta 1 for the short-term effects of radiotherapy and chemotherapy in patients with esophageal cancer, Oncology and Translational Medicine,
  • [3] Antonis Politis;Paolo Olgiati;Petros Malitas;Diego Albani;Alessandra Signorini;Letizia Polito;Stefania De Mauro;Aikaterini Zisaki;Christina Piperi;Evangelia Stamouli;Antonis Mailis;Sara Batelli;Gianluigi Forloni;Diana De Ronchi;Anastasios Kalofoutis;Ioannis Liappas;Alessandro Serretti, Vitamin B12 Levels in Alzheimer's Disease: Association with Clinical Features and Cytokine Production, Journal of Alzheimer's Disease,
  • [4] Maria Werner-Wasik;;Ellen Yorke;;Joseph Deasy;;Jiho Nam;;Lawrence B. Marks, Radiation Dose-Volume Effects in the Esophagus, International Journal of Radiation Oncology, Biology, Physics,

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