Treatment results of childhood extracranial malignant germ cell tumors and the salvage approach for recurrent and refractory cases: a single-center report

【Author】

Kejun He;Xiaojun Yuan;Zhen Tan;Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;

【Institution】

Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;

【Abstract】

Objective The aim of this study is to report the treatment result of childhood excranial malignant germ cell tumors and discuss the experience for recurrent and refractory cases treatment from our center. Methods We have retrospectively analyzed 58 extracranial malignant germ cell tumor patients treated with surgery and chemotherapy from our center over a 9-year period. Another 14 recurrent and refractory cases referred from other centers were added to the study for salvage approach. We evaluated the treatment results for primary cases and relapsed cases with a median follow-up of 61.5 months. Several factors were analysed to evaluate their power to the outcome of these cases.Results The 5-year event-free and overall survival for primary cases were 74.1±5.7% and 86.2±4.5%, respectively. 25 recurrent or refractory cases entered the salvage approach study, and 17 patients were alive till the end of follow-up. We demonstrated superior survival outcome for those with successful local control through pre-operative and post-operative radiotherapy, second-look surgery and multi-drug secondline chemotherapies. Conclusion The outcome for childhood extracranial malignant germ cell tumors is generally favorable. For recurrent and refractory cases, multi-modality treatment approaches including radiotherapy, salvage chemotherapy and secondlook surgery are important for better local control.

【Keywords】

chemotherapy;;germ cell tumor;;radiotherapy;;surgery;;children

References

To explore the background and basis of the node document

Springer Journals Database

Total: 7 articles

  • [1] David Sebag-Montefiore;;Richard J Stephens;;Robert Steele;;John Monson;;Robert Grieve;;Subhash Khanna;;Phil Quirke;;Jean Couture;;Catherine de Metz;;Arthur Sun Myint;;Eric Bessell;;Gareth Griffiths;;Lindsay C Thompson;;Mahesh Parmar, Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial, The Lancet,
  • [2] Marc Schlatter;;Fred Rescorla;;Roger Giller;;Barbara Cushing;;Charles Vinocur;;Paul Colombani;;John Cullen;;Wendy London;;Mary Davis;;Stephen Lauer;;Thomas Olson, Excellent outcome in patients with stage I germ cell tumors of the testes: A study of the Children's Cancer Group/Pediatric Oncology Group, Journal of Pediatric Surgery,
  • [3] Jennifer Y. Wo;;Akila N. Viswanathan, Impact of Radiotherapy on Fertility, Pregnancy, and Neonatal Outcomes in Female Cancer Patients, International Journal of Radiation Oncology, Biology, Physics,
  • [4] M. E. G. Blohm;;D. Vesterling-H&ouml;rner;;G. Calaminus;;U. G&ouml;bel, Alpha<sub>1</sub>-Fetoprotein (AFP) Reference Values in Infants up to 2 Years of Age, Pediatric Hematology-Oncology,

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