Expression of HERG in musculoskeletal tumors with different degrees of malignancy

【Author】

Lu Gan;Mo Li;Tongtao Yang;Jin Wu;Junjie Du;Zhuojing Luo;Yong Zhou;Department of Orthopedics, Air Force Medical University;

【Institution】

Department of Orthopedics, Air Force Medical University;

【Abstract】

Objective The expression of HERG in common bone tumors is scarcely reported and there is a lack of dedicated studies. This study aimed to investigated the expression of HERG in several common musculoskeletal tumors. Methods Immunohistochemical staining, RT-PCR, and Western blotting were used to observe HERG expression differences in various tissues and cell lines. Results HERG was differentially expressed in different malignant tumors, both at a differential protein level and localization within tumors. HERG was not expressed in normal bone tissue. The HERG inhibitor E-4031 markedly inhibited the proliferation of osteosarcoma cell lines.Conclusion HERG was highly expressed in malignant tumors. Blocking of HERG can effectively inhibit the proliferation of bone tumors.

【Keywords】

HERG;;potassium ion channel;;musculoskiletal tumors;;expression

References

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Total: 14 articles

  • [1] Rui Wang;Freddie H.Fu;Bing Wang;Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine;Department of Orthopaedic Surgery, Jinling Hospital, School of Medicine, Nanjing University;, Precision medicine for diagnosis and treatment of osteosarcoma, Oncology and Translational Medicine,
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  • [3] Takahiro Suzuki;;Koichi Takimoto, Selective expression of HERG and Kv2 channels influences proliferationof uterine cancer cells, International Journal of Oncology,
  • [4] Mansoor Abdul;;Naseema Hoosein, Voltage-gated potassium ion channels in colon cancer, Oncology Reports,

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