Insights into African swine fever virus immunoevasion strategies

【Author】

WANG Jun;SHI xin-jin;SUN Hai-wei;CHEN Hong-jun;Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences;

【Institution】

Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences;

【Abstract】

African swine fever(ASF) is an acute and highly contagious disease that causes severe economic losses to the swine industry. ASF is caused by infection of African swine fever virus(ASFV) in domestic pigs, leading to almost 100% mortality. However, no effective vaccines and pharmacologic treatment against ASF are available. ASF poses a severe threat to the swine industry and the economy. Here we summarize potential virus-host cell interaction mechanisms involving the suppression of innate and adaptive immune responses to ASFV entry and infection. These mechanisms include modulation of apoptosis, inhibition of inflammatory responses, reduction of IFN production, inhibition of autophagy, and suppression of MHC-I expression. Insights into immunoevasion strategies by ASFV may shed light on the development of vaccines, as well as preventive and therapeutic drugs.

【Keywords】

African swine fever virus;;immunoevasion;;apoptosis

References

To explore the background and basis of the node document

Springer Journals Database

Total: 37 articles

  • [1] Anthony Orvedahl;;Diane Alexander;;Zsolt Tallóczy;;Qihua Sun;;Yongjie Wei;;Wei Zhang;;Dennis Burns;;David A. Leib;;Beth Levine, HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein, Cell Host & Microbe,
  • [2] Jeffrey C. Boyington;;Aisha N. Riaz;;Apisit Patamawenu;;John E. Coligan;;Andrew G. Brooks;;Peter D. Sun, Structure of CD94 Reveals a Novel C-Type Lectin Fold, Immunity,
  • [3] Sophie Pattingre;;Amina Tassa;;Xueping Qu;;Rita Garuti;;Xiao Huan Liang;;Noboru Mizushima;;Milton Packer;;Michael D. Schneider;;Beth Levine, Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy, Cell,
  • [4] Inmaculada Galindo;;Bruno Hernaez;;Gema Díaz-Gil;;Jose M. Escribano;;Covadonga Alonso, A179L, a viral Bcl-2 homologue, targets the core Bcl-2 apoptotic machinery and its upstream BH3 activators with selective binding restrictions for Bid and Noxa, Virology,

More>>