The toxicological effect of dietary excess of saccharicterpenin,the extract of camellia seed meal,in piglets

【Author】

WANG Man;YU Bing;HE Jun;YU Jie;LUO Yu-heng;LUO Jun-qiu;MAO Xiang-bin;CHEN Dai-wen;Key Laboratory of Animal Disease-Resistance Nutrition,Animal Nutrition Institute,Sichuan Agricultural University;

【Institution】

Key Laboratory of Animal Disease-Resistance Nutrition,Animal Nutrition Institute,Sichuan Agricultural University;

【Abstract】

Recently, saccharicterpenin extracted from Camellia oleifera seed meal has become a widely used feed supplement in animal husbandry. In order to assess its safety, this study was designed to investigate the toxicity and histopathological effects of saccharicterpenin on piglets. One hundred-fifty weaned pigs((Yorkshire×Landrace)×Duroc), 75 males and 75 females with body weight(BW) of(7.35±0.29) kg, were randomly allotted to groups receiving diets supplemented with 0, 500, 1 000, 2 500 or 5 000 mg kg~(–1) saccharicterpenin for 70 d. The diet with 500 mg kg~(–1) saccharicterpenin supplementation improved liver glutathione peroxidase(GSH-Px) activity, and the diet with 1 000 mg kg~(–1) saccharicterpenin supplementation improved liver glutathione S-transferase(GSH-S) activity in piglets on d 70(P<0.05). At 2 500 mg kg~(–1), saccharicterpenin in the diets reduced average daily feed intake(ADFI) and average daily gain(ADG) of piglets from d 1 to 35, damaged the cardiac tissue and liver on d 35, and decreased white blood cell counts(WBC), activities of catalase(CAT) and GSH-Px, and concentrations of glucose(GLU) and urea nitrogen(BUN) in the blood of piglets on d 70(P<0.05). In addition, diets with 5 000 mg kg~(–1) saccharicterpenin supplementation reduced ADFI, ADG and increased diarrhea rates of piglets from d 36 to 70, and decreased hemoglobin(HGB) concentration and activity of CAT in the blood of piglets on d 70(P<0.05). Moreover, at a rate of 5 000 mg kg~(–1), saccharicterpenin supplementation increased pancreas index on d 35 and hepatic index on d 70, and damaged cardiac tissue, liver and spleen during the whole experimental period(P<0.05). These results suggested that dietary 500 mg kg~(–1) saccharicterpenin supplementation had beneficial effects on piglets, but excessive supplementation(2 500 or 5 000 mg kg~(–1)) of saccharicterpenin in the diets could lead to growth retardation, hematological abnormalities and organ injuries.

【Keywords】

growth retardation;;hematology;;organ injury;;piglets;;saccharicterpenin

References

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Springer Journals Database

Total: 38 articles

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