Ana-Marija Hristovska;Lasse E.Rasmussen;Pernille B.L.Hansen;Rolf M.Nusing;Ole Sk■tt;Boye L.Jensen;
<正>In the present study we validated isolated mouse aortic rings for isometric force measurements and addressed pathways by which PGE2 causes vasodilatation and vasoconstriction. Phenylephrine (PE, 10-5M) followed by Acetylcholine (ACh,10-6M) was added at the start of each experiment to test the viability of the smooth muscle and the endothelium, respectively. All experiments were conducted in the presence of the COX-inhibitor Indomethacin (5×10-6M).
PGE_2 causes endothelium-dependent vasodilatation via the EP_4-receptor and endothelium-independent vasoconstriction via the TP-;TP;ECS;EP;
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