Role of cGMP-dependent protein kinase in relaxation of porcine coronary artery induced by nitroglycerin and nitric oxide

【Author】

Xue Qin,Hui Qi & Yuansheng Gao Dept. of Physiology & Pathophysiology, Peking University Health Science Center, Beijing, 100083, China

【Abstract】

<正>Objectives: Relaxation of coronary arteries induced by nitrovasodilators such as nitroglycerin and nitric oxide is primarily mediated by cGMP following the activation of soluble guanylyl cyclase. Cyclic GMP-dependent protein kinase (PKG) is an important target for cGMP action. In coronary arteries, studies shows that PKG activity is stimulated by nitriocvasodilators and that cGMP analogs with high affinities for purified PKG are more effective in causing relaxation. However, there is also studies shows that relaxation of coronary arteries to nitriocvasodilators

【Keywords】

Role of cGMP-dependent protein kinase in relaxation of porcine coronary artery induced by nitroglycerin and nitric oxide;cGMP;

References

To explore the background and basis of the node document

Springer Journals Database

Total: 0 articles

Similar documents

Documents that have the similar content to the node document

More>>