Attenuation of myocardial injury and inhibition of Egr-1 expression with N-n-butyl haloperidol iodide after ischemia and reperfusion

【Author】

Yanmei Zhang,Ganggang Shi & Zhao Tang Department of pharmacology, Shantou University Medical College, China

【Abstract】

<正>N-n-butyl haloperidol iodide(F2) derived from haloperidol was synthesized by our drug research lab. Our previous studies have shown that F2 can antagonize myocardial ischemia/reperfusion (M I/R) injury, which is associated with blocking calcium-channel of cardiac myocyte and vascular smooth muscle membranes.The Egr-1 gene is one of the immediate-early genes. Its product, EGR-1, is a nuclear protein with sequence-specific DNA binding activity. Because EGR-1 can induce expression of multiple downstream target genes, it is believed to act as an

【Keywords】

Attenuation of myocardial injury and inhibition of Egr-1 expression with N-n-butyl haloperidol iodide after ischemia and reperfusion;

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