The PKG mechanism of nitric oxide-induced vasodilatation

【Author】

Yuansheng Gao Peking University Health Science Center, Beijing, China

【Abstract】

<正>Cyclic GMP-dependent protein kinase (PKG) plays a critical role in vasodilation induced by cGMP-elevating agents such as nitric oxide, nitrovasodilators, and natriuretic peptides. In mammalian cells, PKG is present in two forms, PKG I and PKG Ⅱ. The type Ⅰ isoform is the primary enzyme involved in cGMP-dependent regulation of cardiovascular function. PKG may cause vasodilation through the reduction of cytosolic Ca2+ level by stimulating calcium-activated potassium channels, by interfering with the generation of inositol

【Keywords】

PKG;The PKG mechanism of nitric oxide-induced vasodilatation;

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