Calcium channel blockers: past, present and future


T. Godfraind;


<正>Drugs termed nowadays Calcium Channel Blockers (CCBs) were initially named Calcium Antagonists and thereafter Calcium Entry Blockers (CEBs), as recommended by IUPHAR . Changes in terminology of these agents are reflecting the progressive identification of their targets at the molecular level. The first CCBs prototypes were shown to inhibit calcium-evoked contraction in depolarized arteries, producing dose-effect curves similar to those observed in


Calcium channel blockers;


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  • [1] Godfraind T, Calcium-channel modulators for cardiovascular disease, Expert Opin Emerg Drugs,

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