Imaging coordination of contractile activity; effects of cGMP


Christian Aalkj■r;Awahan Rehman;Vladimir Matchkov;Holger Nilsson;


<正>Vasomotion results from the coordinated oscillation of the smooth muscle cells in the vascular wall. Vasomotion occurs in most if not all vascular beds and although the physiological role of vasomotion is unknown it has been suggested to be important for optimal oxygen delivery to tissues. We describe two types of vasomotion. One type of vasomotion is dependent on cyclic release of Ca2+ from the sarcoplasmic reticulum and therefore is a cytosolic oscillator. The coordination of the individual cytosolic oscillators seems to involve a cGMP dependent


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