Therapeutic importance of Rho-kinase in cardiovascular medicine

【Author】

Hiroaki Shimokawa;

【Abstract】

<正>Rho-kinase has been identified as one of the effectors of the small GTP-binding protein Rho. Accumulating evidence has demonstrated that Rho/Rho-kinase pathway plays an important role in various cellular functions, not only in vascular smooth muscle cell (VSMC) contraction but also in actin cytoskeleton organization, cell adhesion and motility, cytokinesis, and gene expressions, all of which may be involved in the pathogenesis of cardiovascular disease. We have been

【Keywords】

Rho;Therapeutic importance of Rho-kinase in cardiovascular medicine;

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